Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia
Identifieur interne : 000332 ( France/Analysis ); précédent : 000331; suivant : 000333Impaired modulation of motor cortex excitability by homonymous and heteronymous muscle afferents in focal hand dystonia
Auteurs : George Lourenço [France] ; Sabine Meunier [France] ; Marie Vidailhet [France] ; Marion Simonetta-Moreau [France]Source :
- Movement Disorders [ 0885-3185 ] ; 2007-03-15.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Dystonia, Dystonia (diagnosis), Dystonia (physiopathology), Dystonia (therapy), Dystonic Disorders (diagnosis), Dystonic Disorders (physiopathology), Dystonic Disorders (therapy), Electromyography, Evoked Potentials, Motor (physiology), Excitability, Female, Hand, Hand (innervation), Hand (physiopathology), Humans, Magnetics (instrumentation), Male, Middle Aged, Modulation, Motor Cortex (physiopathology), Motor cortex, Muscle, Skeletal (innervation), Muscle, Skeletal (physiopathology), Nervous system diseases, Neurons, Afferent (physiology), Posture (physiology), Transcranial Magnetic Stimulation (methods), Transcranial magnetic stimulation, focal hand dystonia, muscle afferent input, sensorimotor system, transcranial magnetic stimulation.
- MESH :
- diagnosis : Dystonia, Dystonic Disorders.
- innervation : Hand, Muscle, Skeletal.
- instrumentation : Magnetics.
- methods : Transcranial Magnetic Stimulation.
- physiology : Evoked Potentials, Motor, Neurons, Afferent, Posture.
- physiopathology : Dystonia, Dystonic Disorders, Hand, Motor Cortex, Muscle, Skeletal.
- therapy : Dystonia, Dystonic Disorders.
- Adolescent, Adult, Aged, Electromyography, Female, Humans, Male, Middle Aged.
Abstract
A decrease of heteronymous median nerve‐evoked inhibition of corticospinal projections to forearm extensor muscles was reported in a group of 10 dystonic patients by Bertolasi and colleagues in 2003. Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median‐induced) but also homonymous (radial‐induced) inhibitions (interstimuli intervals 13–21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median‐induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial‐induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles. © 2006 Movement Disorder Society
Url:
- https://api.istex.fr/document/0CD8D21BC243328F534E5D5A1943CA0E8633FF70/fulltext/pdf
- https://hal.archives-ouvertes.fr/hal-00272387
DOI: 10.1002/mds.21312
Affiliations:
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ISTEX:0CD8D21BC243328F534E5D5A1943CA0E8633FF70Le document en format XML
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Here we tested the excitability of corticomotoneuronal connections to both wrist extensor (ECR) and flexor (FCR) muscles after conditioning stimulation of median and also radial nerve at rest in a group of 25 patients with focal hand dystonia compared to 20 healthy subjects. We also investigated the effect of the wrist dystonic posture, either in flexion or in extension, on the afferent modulation of ECR and FCR motor evolved potentials (MEPs). The heteronymous (median‐induced) but also homonymous (radial‐induced) inhibitions (interstimuli intervals 13–21 ms) of ECR MEP size observed in healthy subjects were decreased in patients. In addition, homonymous (median‐induced) facilitation of FCR MEP size was also decreased in patients while heteronymous inhibition (radial‐induced) was not. Neither the involvement of the target muscle in the dystonic posture nor the origin of the afferent volley (from a dystonic muscle) influenced the degree of impairment of afferent modulation of the MEP. These findings support the view that a global abnormal somatosensory coupling in focal hand dystonia may contribute to an inadequate motor command to wrist muscles. © 2006 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li><li>Toulouse</li></settlement><orgName><li>Université Pierre-et-Marie-Curie</li></orgName></list><tree><country name="France"><noRegion><name sortKey="Lourenco, George" sort="Lourenco, George" uniqKey="Lourenco G" first="George" last="Lourenço">George Lourenço</name></noRegion><name sortKey="Lourenco, George" sort="Lourenco, George" uniqKey="Lourenco G" first="George" last="Lourenço">George Lourenço</name><name sortKey="Meunier, Sabine" sort="Meunier, Sabine" uniqKey="Meunier S" first="Sabine" last="Meunier">Sabine Meunier</name><name sortKey="Meunier, Sabine" sort="Meunier, Sabine" uniqKey="Meunier S" first="Sabine" last="Meunier">Sabine Meunier</name><name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name><name sortKey="Simonetta Oreau, Marion" sort="Simonetta Oreau, Marion" uniqKey="Simonetta Oreau M" first="Marion" last="Simonetta-Moreau">Marion Simonetta-Moreau</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name><name sortKey="Vidailhet, Marie" sort="Vidailhet, Marie" uniqKey="Vidailhet M" first="Marie" last="Vidailhet">Marie Vidailhet</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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